HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Sertraline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;2-hydroxy-2-phenylacetate | HCID 131718189 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Sertraline | HCID 68617 | 191.2% |
| Product | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;2-hydroxy-2-phenylacetate | HCID 131718189 | — |
Reaction Steps
Sertraline mandelate was prepared according to procedures in U.S. Pat. No. 5,248,699. Sertraline mandelate (5 g) was stirred at room temperature with 50 mL ethyl acetate. Aqueous sodium hydroxide was added dropwise until the sertraline mandelate was completely neutralized. The phases were separated and the organic phase was dried over MgSO4 and filtered. The solvent was removed under reduced pressure resulting sertraline base as an oil (3.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495721B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-c076d909bfa643ebb9f76503fc68dd92 |
| Source note | uspto-grants-2002_12 |