反应详情

To a suspension of but-3-butenylbenzene (3 ml) and sodium hydrogen carbonate (2.5 g) in a mixture of dichloromethane (200 ml) and water (60 ml) was added small portions of m-chloroperbenzoic acid (3.5 g) at room temperature, and the mixture was stirred at the same temperature for 4 hours. After separation, the organic layer was successively washed with saturated aqueous sodium hydrogencarbonate and brine, dried over anhydrous magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=100:3) to give 2-phenethyloxirane (970 mg).

1. customAfter separation
2. washthe organic layer was successively washed with saturated aqueous sodium hydrogencarbonate and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customevaporated in vacuo
5. customThe residue was purified by column chromatography on silica gel (hexane:ethyl acetate=100:3)