HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2299652Generated: October 27, 2026
Methyl iodide → 3-Methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one
https://huagongshe.com/reaction/2299652
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-hydroxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one | HCID 229507 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-Methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one | HCID 13357441 | 72.4% |
Reaction Steps
A mixture of 3-hydroxy-6,7,8,9-tetrahydrobenzocyclohepten-5-one (7.02 g), potassium carbonate (8.25 g) and iodomethane (7.4 ml) in N,N-dimethylformamide (70 ml) was stirred at 50-55° C. for 7 hours. The resulting mixture was diluted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo to afford 3-methoxy-6,7,8,9-tetrahydrobenzocyclohepten-5-one (5.49 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06495546B1 |
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| Source dataset | uspto-grants-2002_12 |
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| ORD ID | ord-3d383ff086c34447b9c342bf18c762a5 |
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| Source note | uspto-grants-2002_12 |
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