Sodium Hydroxide → HCID 69329963, compound

Participants

Reaction Steps

8-[(2S)-2-Hydroxy-3-phenoxypropyl]amino-6,7,8,9-tetrahydro-5H-benzocycloheptene-2-carboxylic acid methyl ester hydrochloride was converted to the corresponding free base in a usual manner. A solution of the base (91 mg) in methanol (1 ml) and 1N sodium hydroxide aqueous solution (0.246 ml) was stirred at 70° C. for 6 hours and evaporated in vacuo. The residue was triturated in diisopropyl ether, and the precipitated powder was collected by filtration to afford sodium 8-[(2S)-2-hydroxy-3-phenoxypropyl]amino-6,7,8,9-tetrahydro-5H-benzocycloheptene-2-carboxylate (74 mg).

Provenance & Evidence