Dichloromethane → HCID 69330970, compound

Participants

Reaction Steps

Under nitrogen, to a solution of 2-[8-[(2R)-2-hydroxy-2-(4-hydroxy-3-methanesulfonylaminophenyl)ethylamino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yloxy]acetic acid tert-butyl ester (257 mg) in dichloromethane (5 ml) was added trifluoroacetic acid (1 ml) at 5° C., and the mixture was stirred at room temperature for 3 hours. The resulting mixture was evaporated in vacuo. The residue was treated with 4N hydrogen chloride in 1,4-dioxane to give 2-[8-[(2R)-2-hydroxy-2-(4-hydroxy-3-methanesulfonylaminophenyl)ethylamino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yloxy]acetic acid hydrochloride (247 mg).

Provenance & Evidence