2-(Methylamino)ethanol → Ethanol, 2-(methyl-2-pyrimidinylamino)-

HRID 2299720Notes

Reaction equation

HRID 2299720 reaction equation
Cl[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:8][NH:9][CH2:10][CH2:11][OH:12]>>[CH3:8][N:9]([C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1)[CH2:10][CH2:11][OH:12]

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 744042-Chloropyrimidine

Product 1

HCID 10419381Ethanol, 2-(methyl-2-pyrimidinylamino)-Yield 88%

Conditions

Temperature
120 °C

Procedure

A mixture of 2-chloropyrimidine (20.8 g) and 2-(methylamino)ethanol (180 ml) was heated at 120° C. for 15 hours and concentrated. The residue was dissolved in ethyl acetate, washed with an aqueous saturated solution of sodium chloride, dried (MgSO4) and concentrated. The residue was distilled under reduced pressure to obtain 2-(methyl-2-pyrimidylamino)ethanol (24.6 g, yield 88%) as a colorless oil. b.p. 130-132° C./1-1.5 mmHg

Workup

  1. concentrationconcentrated
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washwashed with an aqueous saturated solution of sodium chloride
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated
  6. distillationThe residue was distilled under reduced pressure

Sources & evidence

ORD record
ord-d4ec62c64a574487b818dc586fbbe6a7
Source dataset
uspto-grants-2002_12
Patent number
US06495581B1

Reaction notes

Loading…