HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3,5-Dimethoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 3,5-Dimethoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde | HCID 22344579 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3,5-Dimethoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl alcohol | HCID 53674158 | 92% |
Reaction Steps
Sodium borohydride (540 mg) was added to a solution of 3,5-dimethoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde (10.0 g) in tetrahydrofuran (70 ml)-methanol (30 ml) at 0° C. After stirring for 1 hour, the reaction mixture was poured into water to give 3,5-dimethoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl alcohol (9.25 g, yield 92%) as crystals. Recrystallization from ethyl acetate-hexane gave colorless prisms. m.p. 113-114° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495581B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-ea3ec0d84f2449dc93b40c6cbe8f00cf |
| Source note | uspto-grants-2002_12 |