Methylamine → HCID 67485059, compound

Participants

Reaction Steps

The title compound of Example 11 Step A (15.2 mmol, 3.01 g) was stirred in 15 mL of 2 M methylamine in THF at 0° C. After the reaction was complete, the reaction mixture was concentrated under reduced pressure and the residue was partitioned into DCM/brine. The organic phase was concentrated under reduced pressure affording the product as a bright yellow solid. 1H NMR (500 MHz, d6-DMSO): δ 8.03 (d, 1H), 6.30-6.36 (overlapping m, 2H), 6.06 (m, 1H), 5.44 (m, 1H), 5.31 (m, 1H), 2.96 (d, 3H). MS (ESI): m/z 209 (M+H). HPLC A: 2.20 min.

Provenance & Evidence