HuagongsheHuagongshe Chemistry Print Report · For research reference only
3(RS)-(3-Biphenyl-4-yl-1H-imidazol-1-yl)-N-(hexahydroazepin-2-on-3(S)-yl]succinamic Acid Benzyl Ester → 3(RS)-(3-biphenyl-4-yl-1H-imidazol-1-yl)-N-(hexahydroazepin-2-on-3(S)-yl)succinamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3(RS)-(3-Biphenyl-4-yl-1H-imidazol-1-yl)-N-(hexahydroazepin-2-on-3(S)-yl]succinamic Acid Benzyl Ester | HCID 53846884 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3(RS)-(3-biphenyl-4-yl-1H-imidazol-1-yl)-N-(hexahydroazepin-2-on-3(S)-yl)succinamic acid | HCID 18341321 | 94% |
Reaction Steps
According to the procedure described in Example 1(a), a suspension of 3(RS)-(3-biphenyl-4-yl-1H-imidazol-1-yl)-N-(hexahydroazepin-2-on-3(S)-yl)succinamic acid benzyl ester in EtOH was hydrogenolyzed after 90 minutes to provide 779 mg(94%) of 3(RS)-(3-biphenyl-4-yl-1H-imidazol-1-yl)-N-(hexahydroazepin-2-on-3(S)-yl)succinamic acid as a solid. FABMS: 447 (C25H27N4O4; M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495699B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-c6bb937bd8a74d0cab824401c25de4dc |
| Source note | uspto-grants-2002_12 |