HCID 53753146, compound → HCID 18341320, compound

HRID 2300017Notes

Reaction equation

HRID 2300017 reaction equation
C([O:8][C:9](=[O:41])[CH2:10][CH:11]([N:24]1[CH:28]=[CH:27][N:26]([C:29]2[CH:34]=[CH:33][C:32]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)=[CH:31][CH:30]=2)[CH2:25]1)[C:12]([NH:14][C@H:15]([C:20](=[O:23])[NH:21][CH3:22])[C:16]([CH3:19])([CH3:18])[CH3:17])=[O:13])C1C=CC=CC=1>CCO>[C:32]1([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH:31]=[CH:30][C:29]([N:26]2[CH:27]=[CH:28][N:24]([CH:11]([C:12]([NH:14][C@H:15]([C:20](=[O:23])[NH:21][CH3:22])[C:16]([CH3:19])([CH3:17])[CH3:18])=[O:13])[CH2:10][C:9]([OH:41])=[O:8])[CH2:25]2)=[CH:34][CH:33]=1

Participants

3

Reactant 1

HCID 53753146HCID 53753146, compound

Product 1

HCID 18341320HCID 18341320, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

According to the procedure described in in Example 1(a), a suspension of 3(RS)-(3-biphenyl-4-yl-1H-imidazol-1-yl)-N-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)succinamic acid benzyl ester in EtOH was hydrogenated to provide 3(RS)-(3-biphenyl-4-yl-1H-imidazol-1-yl)-N-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)succinamic acid as a solid, mp 187.0-8.2° C. FABMS: 463.2 (C26H31N4O4; M+H+).

Sources & evidence

ORD record
ord-b6289215d57341e684c23c02048086e6
Source dataset
uspto-grants-2002_12
Patent number
US06495699B2

Reaction notes

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