Aniline → HCID 11298997, compound

Participants

Reaction Steps

A mixture of aniline (9.30 g, 0.10 mol), 2-bromopropionate t-butyl ester 20.9 g, 0.10 mol), Hunig's base (12.90 g, 0.10 mol) and toluene (200 mL) were stirred at reflux for 16 hours. The salt that formed was removed by filtration and the filtrate concentrated in vacuo to an oil (20 g). The oil was distilled. Pure N-phenylalanine t-butyl ester (18.0 g, 81% yield) was collected at 105-115 C (0.08 mm Hg).

Provenance & Evidence