Ethylamine → HCID 18374883, compound

HRID 2300065Notes

Reaction equation

HRID 2300065 reaction equation
[CH3:1][N:2]1[C:7]2[N:8]=[C:9](S(C)(=O)=O)[N:10]=[CH:11][C:6]=2[CH:5]=[CH:4][C:3]1=[O:16].[CH2:17]([NH2:19])[CH3:18]>>[CH2:17]([NH:19][C:9]1[N:10]=[CH:11][C:6]2[CH:5]=[CH:4][C:3](=[O:16])[N:2]([CH3:1])[C:7]=2[N:8]=1)[CH3:18]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 18374925HCID 18374925, compound

Product 1

HCID 18374883HCID 18374883, compoundYield 82%

Procedure

A mixture of 8-methyl-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one (152 mg, 0.63 mmol) in 2.5 mL of 70% aqueous ethylamine was stirred at room temperature for 10 minutes. The reaction mixture was partitioned between ethyl acetate and water, and the organic layer was washed with saturated sodium bicarbonate and brine, dried over magnesium sulfate, and concentrated in vacuo to give 105 mg (82%) of 2-ethylamino 8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, mp 194-195° C.

Workup

  1. customThe reaction mixture was partitioned between ethyl acetate and water
  2. washthe organic layer was washed with saturated sodium bicarbonate and brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b9c667cd1a654c8f91da9df3f7754d75
Source dataset
uspto-grants-2002_12
Patent number
US06498163B1

Reaction notes

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