Ethylamine → HCID 18374937, compound

HRID 2300083Notes

Reaction equation

HRID 2300083 reaction equation
CS([C:4]1[N:5]=[CH:6][C:7]2[CH:13]=[CH:12][C:11](=[O:14])[N:10]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:8]=2[N:9]=1)=O.[CH2:21]([NH2:23])[CH3:22]>>[CH2:21]([NH:23][C:4]1[N:5]=[CH:6][C:7]2[CH:13]=[CH:12][C:11](=[O:14])[N:10]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:8]=2[N:9]=1)[CH3:22]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 10731849HCID 10731849, compound

Product 1

HCID 18374937HCID 18374937, compoundYield 72%

Procedure

A mixture of 2-methanesulfinyl-8-phenyl-8H-pyrido[2,3-d]pyrimidin-7-one (81 mg, 0.28 mmol) and 1.5 mL of aqueous ethyl amine was stirred at room temperature for 10 minutes then partitioned between water and ethyl acetate. The organic layer was washed with saturated sodium bicarbonate and brine, dried over magnesium sulfate, filtered, and concentrated in vacuo to give 54 mg (72%) of 2-ethylamino-8-phenyl-8H-pyrido[2,3-d]pyrimidin-7-one, mp 193-195° C.

Workup

  1. customthen partitioned between water and ethyl acetate
  2. washThe organic layer was washed with saturated sodium bicarbonate and brine
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5f474e7b9dc44549b837356d659160b7
Source dataset
uspto-grants-2002_12
Patent number
US06498163B1

Reaction notes

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