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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2300105Generated: October 27, 2026

4-Bromothiophene-2-carbonitrile → 4-(2-Methylspiro[2H-3,1-benzoxazine-4,1'-cyclopentane]-6-yl)-2-thiophenecarbonitrile

https://huagongshe.com/reaction/2300105

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromothiophene-2-carbonitrileHCID 14292355—
Reactant2-methyl-6-bromospiro[4H-3,1-benzoxazine-4,1'-cyclopentane]HCID 23435585—
Product4-(2-Methylspiro[2H-3,1-benzoxazine-4,1'-cyclopentane]-6-yl)-2-thiophenecarbonitrileHCID 23435612—

Reaction Steps

Prepared according to the procedure for Example 13 from 2-methyl-6-bromospiro[4H-3,1-benzoxazine-4,1′-cyclopentane] and 4-bromo-2-thiophenecarbonitrile. An off-white solid: mp 103-104° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06498154B1
Source datasetuspto-grants-2002_12
ORD IDord-6bf5acfdd0474d79b33008f21679f230
Source noteuspto-grants-2002_12