HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2300131Generated: November 3, 2026
Formic Acid → N-[4-methoxy-3-(trifluoromethyl)benzyl]formamide
https://huagongshe.com/reaction/2300131
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Formamide | HCID 713 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Methoxy-3-(trifluoromethyl)benzaldehyde | HCID 2775291 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-[4-methoxy-3-(trifluoromethyl)benzyl]formamide | HCID 22744421 | — |
Reaction Steps
A mixture of 5.8 g 3-trifluoromethyl-p-anisaldehyde, 8.6 ml formamide, and 13.6 ml formic acid was stirred at 130° C. for 9 hr. After cooling, water and ethyl acetate were added thereto. The ethyl acetate layer was recovered and washed with brine. It was dried over anhydrous magnesium sulfate, filtered, and evaporated. The resulting residue was purified by silica gel column chromatography to give 3.8 g of N-[4-methoxy-3-(trifluoromethyl)benzyl]formamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06498159B1 |
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| Source dataset | uspto-grants-2002_12 |
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| ORD ID | ord-6687c211faa74f90ad4a2435468d95bf |
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| Source note | uspto-grants-2002_12 |
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