HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,8-Diazabicyclo(5.4.0)undec-7-ene → 1-Chloro-4-[(3-cyano-4-methoxybenzyl)amino]-6-phthalazine carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 1,4-Dichlorophthalazine-6-carbonitrile | HCID 10656738 | — |
| Reactant | 5-(Aminomethyl)-2-methoxybenzonitrile | HCID 22744645 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1-Chloro-4-[(3-cyano-4-methoxybenzyl)amino]-6-phthalazine carbonitrile | HCID 86588311 | — |
Reaction Steps
1,4-Dichlorophthalazine-6-carbonitrile and 3-cyano-4-methoxybenzylamine were stirred at room temperature in 1-methyl-2-pyrrolidinone in the presence of DBU, whereby 1-chloro-4-[(3-cyano-4-methoxybenzyl)amino]-6-phthalazine carbonitrile was obtained as a less polar product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06498159B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-43b18d082b93418283bb9d0d3954e3a8 |
| Source note | uspto-grants-2002_12 |