HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,8-Diazabicyclo(5.4.0)undec-7-ene → 1-Chloro-4-[(4-chloro-3-methoxybenzyl)amino]-6-phthalazine carbonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Edukt | 1,4-Dichlorophthalazine-6-carbonitrile | HCID 10656738 | — |
| Edukt | 4-Chloro-3-methoxybenzylamine benzylamine hydrochloride | HCID 22744481 | — |
| Lösungsmittel | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Produkt | 1-Chloro-4-[(4-chloro-3-methoxybenzyl)amino]-6-phthalazine carbonitrile | HCID 18374614 | — |
Reaktionsschritte
4-Chloro-3-methoxybenzylamine benzylamine hydrochloride synthesized according to the method described in WO9518097 and 1,4-dichlorophthalazine-6-carbonitrile were stirred at room temperature in 1-methyl-2-pyrrolidinone in the presence of DBU, whereby 1-chloro-4-[(4-chloro-3-methoxybenzyl)amino]-6-phthalazine carbonitrile was obtained as a less polar product.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06498159B1 |
| Quelldatensatz | uspto-grants-2002_12 |
| ORD ID | ord-55056f78afdd4ced9e9881d3cba425ac |
| Quellennotiz | uspto-grants-2002_12 |