HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-4-((3-chloro-4-methoxybenzyl)amino)-6-phthalazinecarbonitrile → 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-[4-hydroxy-4-(hydroxymethyl)piperidino]phthalazine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-4-((3-chloro-4-methoxybenzyl)amino)-6-phthalazinecarbonitrile | HCID 10451065 | — |
| Reactant | 4-(Hydroxymethyl)-4-piperidinol hydrochloride | HCID 22744472 | — |
| Product | 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-[4-hydroxy-4-(hydroxymethyl)piperidino]phthalazine Hydrochloride | HCID 18374623 | — |
Reaction Steps
The resulting 4-(hydroxymethyl)-4-piperidinol hydrochloride was reacted with 1-chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine in the same manner as in Example 4 to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06498159B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-c7550f5e25524745b6835faf0941798a |
| Source note | uspto-grants-2002_12 |