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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2300220Generated: November 1, 2026

Benzylamine → N-[5-((1R)-2-Benzylamino-1-triethylsilanyloxy-ethyl)-2-benzyloxy-phenyl]-methanesulfonamide

https://huagongshe.com/reaction/2300220

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzylamineHCID 7504—
Reactant(R)-N-[2-benzyloxy-5-(2-iodo-1-triethylsilyloxyethyl)phenyl]methanesulfonamideHCID 54211801—
ProductN-[5-((1R)-2-Benzylamino-1-triethylsilanyloxy-ethyl)-2-benzyloxy-phenyl]-methanesulfonamideHCID 69952868—

Reaction Conditions

Temperature65 °C

Reaction Steps

N-[2-benzyloxy-5-((1R)-2-iodo-1-triethylsilanyloxy-ethyl)-phenyl]-methanesulfonamide (0.56 g, 1 mmol) was dissolved in benzylamine (0.54 g, 5 mmol) and stirred at 65° C. for 22 h.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06498170B2
Source datasetuspto-grants-2002_12
ORD IDord-b6729127be5c4404976737f800b37e49
Source noteuspto-grants-2002_12