Triethylamine → HCID 18767822, compound

Participants

Reaction Steps

To a solution of DL-3-pyrrolidinol (0.87 g, 10 mmol) in dichloromethane (10 ml) was added triethylamine (1.21 g, 12 mmol) and 4-butoxybezenesulfonyl chloride (2.69 g, 10.5 mmol). The mixture was stirred at room temperature for 2 h. It was then treated with 10 ml of saturated sodium carbonate solution for 18 h. The mixture was diluted with water, and the organic solvents were evaporated. The resulting suspension was filtered, and the precipitate was washed with water and hexanes, and dried to give 2.89 g of an off-white solid; m.p. 83-84° C.; MS (ES) m/z 299.9 (MH+); HRMS (Cl) Calcd. for C14H22NO4S (MH+): 300.1269, Found: 300.1272.

Provenance & Evidence