HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (ethoxymethylene)malonate → Diethyl {[(1-phenyl-5-pyrazolyl)amino]methylene}malonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 1-Phenylpyrazol-5-ylamine | HCID 70006 | — |
| Product | Diethyl {[(1-phenyl-5-pyrazolyl)amino]methylene}malonate | HCID 22322171 | — |
Reaction Steps
A mixture of 15.9 g. (0.10 mole) of 1-phenyl-5-aminopyrazole and 21.6 g. (0.10 mole) of diethyl ethoxymethylenemalonate was heated at 115-120° in an oil bath for 2 hours. After cooling, the crystalline mass was recrystallized from hot hexane containing 1% of ethanol. Cooling to room temperature and filtering gave 24.8 g. (75%) of off-white crystals, m.p. 96-97° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06498167B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-c0b64331f8024647b06e2136462e4d13 |
| Source note | uspto-grants-2002_12 |