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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2300293Generated: October 30, 2026

Water → HCID 22557990, compound

https://huagongshe.com/reaction/2300293

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
Reactant4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridineHCID 12019237—
ReactantPhthalimide potassium saltHCID 24194345—
SolventChloroformHCID 6212—
ProductHCID 22557990HCID 22557990—

Reaction Steps

To a solution of 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (881 mg) in chloroform (10 mL) was added potassium phthalimide (556 mg). The mixture was stirred at room temperature overnight and water was added. After separating the organic layer, the aqueous layer was extracted with chloroform. Organic layers were combined, dried over anhydrous magnesium sulfate and evaporated to give the title compound as white powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06498169B1
Source datasetuspto-grants-2002_12
ORD IDord-a370cc194b184a759c70002854e8355b
Source noteuspto-grants-2002_12