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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2300299Generated: October 31, 2026

Potassium Hydroxide → 2-(3,4,5-Trimethoxyphenyl)pyridine-4-carboxylic acid

https://huagongshe.com/reaction/2300299

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
ReactantEthyl 2-(3,4,5-trimethoxyphenyl)pyridine-4-carboxylateHCID 16125879—
SolventEthanolHCID 702—
Product2-(3,4,5-Trimethoxyphenyl)pyridine-4-carboxylic acidHCID 12043485—

Reaction Steps

To a solution of ethyl 2-(3,4,5-trimethoxyphenyl)isonicotinate (3.17 g) in ethanol (40 mL) was added 10% potassium hydroxide (2.42 g). The mixture was stirred at room temperature for 5 hours and evaporated. Water was added to the residue and pH was adjusted to 7. White precipitates of the title compound were collected by filtration and the Compound was used for next step without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06498169B1
Source datasetuspto-grants-2002_12
ORD IDord-c6b45a7e0aa941c89c5c0c4af6d46699
Source noteuspto-grants-2002_12