Ethyl 2-bromobenzoate → Ethyl 2-(3,4,5-trimethoxyphenyl)benzoate

HRID 2300333Notes

Reaction equation

HRID 2300333 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].Br[C:17]1[CH:27]=[CH:26][CH:25]=[CH:24][C:18]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:17][C:18]=2[C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 80186Ethyl 2-bromobenzoateHCID 27343903,4,5-Trimethoxybenzeneboronic acid

Product 1

HCID 22558004Ethyl 2-(3,4,5-trimethoxyphenyl)benzoate

Procedure

3,4,5-Trimethoxyphenylboronic acid (639 mg) and ethyl 2-bromobenzoate (479 mg) were condensed in the same manner as described in Preparation Example 1 to give the title compound.

Workup

  1. customcondensed in the same manner
  2. customas described in Preparation Example 1

Sources & evidence

ORD record
ord-d863cb1affb049baa5e226ffc531b70d
Source dataset
uspto-grants-2002_12
Patent number
US06498169B1

Reaction notes

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