Tetrafluoro-m-phenylenediamine dihydrochloride → 4-[N-(3,4-methylenedioxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl) benzyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine dihydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Tetrafluoro-m-phenylenediamine dihydrochloride	HCID 149026	—
Reactant	3-(3,4,5-Trimethoxyphenyl)benzyl chloride	HCID 12021157	—
Reactant	4-(3,4-Methylenedioxyphenylamino)-1-[[2-(3,4,5-trimethoxyphenyl) pyridin-4-yl]methyl]piperidine	HCID 12043487	—
Product	4-[N-(3,4-methylenedioxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl) benzyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine dihydrochloride	HCID 18174246	—

Reaction Steps

4-(3,4-Methylenedioxyphenylamino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine (119 mg) and 3-(3,4,5-trimethoxyphenyl)benzyl chloride (114 mg) were condensed by the same manner as described in Example 9. Yellow oil of a free base was converted to a dihydrochloride which gave the title compound as yellow powder.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06498169B1
Source dataset	uspto-grants-2002_12
ORD ID	ord-77459686a207491bb5361496902ee464
Source note	uspto-grants-2002_12