HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine → 4-[N-methyl-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine tetrahydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine | HCID 12019237 | — |
| Reactant | 4-(Methylamino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine | HCID 22557850 | — |
| Product | 4-[N-methyl-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine tetrahydrochloride | HCID 22557939 | — |
Reaction Steps
4-(methylamino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine (2.67 g) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (2.12 g) were condensed in the same manner as described in Example 2. The title compound was obtained after converting a free base to a tetrahydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06498169B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-525a11fdb43f4ba09c2aa2d717d871ce |
| Source note | uspto-grants-2002_12 |