4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine → 4-[N-methyl-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine tetrahydrochloride

Participants

Role	Name	HCID	Charge
Reactant	4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine	HCID 12019237	—
Reactant	4-[N-methyl-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]piperidine	HCID 22557863	—
Product	4-[N-methyl-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine tetrahydrochloride	HCID 22557939	—

Reaction Steps

4-[N-methyl-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]piperidine (73 mg) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (58 mg) were condensed in the same manner as described in Example 2. The title compound was obtained after converting a free base to a tetrahydrochloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06498169B1
Source dataset	uspto-grants-2002_12
ORD ID	ord-4ef5f8e24332414f93e59ef697b917f7
Source note	uspto-grants-2002_12