HCID 22557787, compound → HCID 22557849, compound

HRID 2300359Notes

Reaction equation

HRID 2300359 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][N:20]=[C:19]([C:23]4[CH:28]=[C:27]([O:29][CH3:30])[C:26]([Cl:31])=[C:25]([O:32][CH3:33])[CH:24]=4)[CH:18]=3)[CH2:12][CH2:11]2)=[CH:5][CH:4]=1.[Cl:34][C:35]1[C:40]([O:41][CH3:42])=[CH:39][C:38]([C:43]2[CH:48]=[C:47]([CH2:49]Cl)[CH:46]=[CH:45][N:44]=2)=[CH:37][C:36]=1[O:51][CH3:52]>>[ClH:31].[ClH:34].[ClH:31].[Cl:31][C:26]1[C:25]([O:32][CH3:33])=[CH:24][C:23]([C:19]2[CH:18]=[C:17]([CH2:16][N:13]3[CH2:12][CH2:11][CH:10]([N:9]([CH2:49][C:47]4[CH:46]=[CH:45][N:44]=[C:43]([C:38]5[CH:39]=[C:40]([O:41][CH3:42])[C:35]([Cl:34])=[C:36]([O:51][CH3:52])[CH:37]=5)[CH:48]=4)[C:6]4[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=4)[CH2:15][CH2:14]3)[CH:22]=[CH:21][N:20]=2)=[CH:28][C:27]=1[O:29][CH3:30]

Participants

3

Reactant 2

HCID 22557787HCID 22557787, compoundHCID 22557836HCID 22557836, compound

Product 1

HCID 22557849HCID 22557849, compound

Procedure

4-(p-Anisidino)-1-[[2-(4-chloro-3,5-dimethoxyphenyl)pyridin-4-yl]methyl]piperidine (271 mg) and 2-(4-chloro-3,5-dimethoxyphenyl)-4-chloromethylpyridine (173 mg) were condensed in the same manner as described in Example 9. The title compound was obtained as yellow powder after converting a free base to a trihydrochloride.

Workup

  1. customcondensed in the same manner

Sources & evidence

ORD record
ord-5d2e8272bffc43dfa5783296f5dfd4d1
Source dataset
uspto-grants-2002_12
Patent number
US06498169B1

Reaction notes

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