HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3,4,5-Trimethoxyphenyl)benzyl chloride → 4-[N-(3-Methylthiophenyl)-N-[2-(3,4,5-trimethoxyphenyl)benzyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine Dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3,4,5-Trimethoxyphenyl)benzyl chloride | HCID 12016329 | — |
| Reactant | 4-(3-Methylthioanilino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine | HCID 22557887 | — |
| Product | 4-[N-(3-Methylthiophenyl)-N-[2-(3,4,5-trimethoxyphenyl)benzyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine Dihydrochloride | HCID 68919445 | — |
Reaction Steps
4-(3-Methylthioanilino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine (143 mg) and 2-(3,4,5-trimethoxyphenyl)benzyl chloride (114 mg) were condensed in the same manner as described in Example 9. The title compound was obtained as yellow powder after converting a free base to a dihydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06498169B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-eab2cd6cd6ea4f599458f6240ed4f932 |
| Source note | uspto-grants-2002_12 |