HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Acetyl-5-nitroindole → 5-Amino-7-acetylindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Acetyl-5-nitroindole | HCID 15541434 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Amino-7-acetylindole | HCID 15453469 | 95% |
Reaction Steps
A solution of 7-acetyl-5-nitroindole (0.2 g, 1.2 mmol) and 10% Pd/C (30 mg) in 20 mL of MeOH was stirred at reflux for 1 h. The reaction mixture was filtered and concentrated in vacuo, yielding oil (0.17 g, >95%), which was characterized by NMR and subjected to the following reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06498177B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-9920b0f18d2b4aceb4557cbdf5eb398a |
| Source note | uspto-grants-2002_12 |