4-(1,3-Thiazol-2-yl)benzaldehyde → 7-(4-Thiazol-2-yl-benzylamino)-heptanoic acid methyl ester

HRID 2300428Notes

Reaction equation

HRID 2300428 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH2:11].[S:13]1[CH:17]=[CH:16][N:15]=[C:14]1[C:18]1[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=1>>[CH3:2][O:3][C:4](=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][CH2:22][C:21]1[CH:20]=[CH:19][C:18]([C:14]2[S:13][CH:17]=[CH:16][N:15]=2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 105356554-(1,3-Thiazol-2-yl)benzaldehydeHCID 13807349Methyl 7-aminoheptanoate hydrochloride

Product 1

HCID 542806757-(4-Thiazol-2-yl-benzylamino)-heptanoic acid methyl ester

Procedure

The title compound was prepared following the procedure described in Step A of Example 1 from 7-amino-heptanoic acid methyl ester hydrochloride, of Preparation 1, and 4-thiazol-2-yl-benzaldehyde, of Preparation 25. 1H NMR (400 MHz, CDCl3) δ 7.91 (d, 2H), 7.84 (d, 1H), 7.38 (d, 2H), 7.30 (d, 1H), 3.82 (s, 2H), 3.65 (s, 3H), 2.62 (t, 2H), 2.29 (t, 2H), 1.61 (m, 2H), 1.51 (m, 2H), 1.33 (m, 4H); MS 333 (M+1).

Sources & evidence

ORD record
ord-0b6f6c73f4ff44569764075791094bbc
Source dataset
uspto-grants-2002_12
Patent number
US06498172B1

Reaction notes

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