4-(1H-Pyrazol-1-yl)benzaldehyde → 7-(4-Pyrazol-1-yl-benzylamino)-heptanoic acid methyl ester

HRID 2300433Notes

Reaction equation

HRID 2300433 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH2:11].[N:13]1([C:18]2[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=2)[CH:17]=[CH:16][CH:15]=[N:14]1>>[CH3:2][O:3][C:4](=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][CH2:22][C:21]1[CH:20]=[CH:19][C:18]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 27764774-(1H-Pyrazol-1-yl)benzaldehydeHCID 13807349Methyl 7-aminoheptanoate hydrochloride

Product 1

HCID 539304737-(4-Pyrazol-1-yl-benzylamino)-heptanoic acid methyl ester

Procedure

The title compound of Step A was prepared from 7-amino-heptanoic acid methyl ester hydrochloride, of Preparation 1, and 4-pyrazol-1-yl-benzaldehyde, of Preparation 42, using the method described in Example 1, Step A. 1H NMR (400 MHz, CDCl3) δ 7.90 (m, 1H), 7.70 (d, 1H), 7.63 (d, 2H), 7.39 (d, 2H), 6.45 (m, 1H), 3.80 (s, 2H), 3.65 (s, 3H), 2.61 (t, 2H), 2.29 (t, 2H), 1.63-1.32 (m, 4H), 1.25 (m, 4H); MS 316 (M+1).

Sources & evidence

ORD record
ord-f4b4f9b539d34d82bd5c4162b943995b
Source dataset
uspto-grants-2002_12
Patent number
US06498172B1

Reaction notes

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