5-(4-Formylphenyl)pyrimidine → 3-{3-[(4-Pyrimidin-5-yl-benzylamino)-methyl]-phenyl}propionic acid methyl ester

Participants

Reaction Steps

The title compound of Step A was prepared from 3-(3-aminomethyl--phenyl)-propionic acid methyl ester hydrochloride salt, of Preparation 44, and 4-pyrimidin-5-yl-benzaldehyde, of Preparation 26, using the method described in Example 1, Step A except the imine was formed in MeOH at reflux over 2 h. 1H NMR (400 MHz, CDCl3)δ 9.19 (s, 1H), 8.92 (s, 2H), 7.55 (m, 4H), 7.25 (m, 3H), 7.11 (d, 1H), 3.87 (s, 2H), 3.81 (s, 2H), 3.66 (s, 3H), 2.95 (t, 2H), 2.63 (t, 2H); MS 362 (M+1).

Provenance & Evidence