Iodoacetamide → HCID 131727434, compound

Participants

Reaction Conditions

Reaction Steps

2-Iodoacetamide (1.13 g) was added to a solution of 1.46 g of allyl (1S,5R,6S)-6-[(1R)-1-hydroxyethyl]-2-[7-(pyridin-3-yl)carbonyl-imidazo[5,1-b]thiazol-2-yl]-1-methylcarbapen-2-em-3-carboxylate in 4.5 ml of methanol, and the mixture was stirred at 40° C. for 22 hr. Methanol (8 ml) was added thereto for dilution. The diluted reaction mixture was added dropwise to 180 ml of ethyl acetate, and the resultant powder was collected by filtration to give 1.80 g of allyl (1S,5R,6S)-2-[7-(1-carbamoylmethylpyridinium-3-yl)carbonylimidazo[5,1-b]thiazol-2-yl]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate iodide.

Provenance & Evidence