2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde → HCID 54016659, compound

Participants

Reaction Steps

The title compound of Step A was prepared from 3-(3-aminomethyl-phenyl)-propionic acid methy ester hydrochloride salt, of Preparation 44, and 2,3- dihydro-benzo[1,4]-dioxine-6-carbaldehyde using the method described in Example 1, Step A except the imine was formed in MeOH at reflux over 3 h. 1H NMR (400 MHz, CDCl3) δ 7.26-7.16 (m, 3H), 7.07 (d, 1H), 6.85-6.78 (m, 3H), 4.24 (s, 4H), 3.75 (s, 2H), 3.68 (s, 2H), 3.66 (s, 3H), 2.94 (t, 2H), 2.62 (t, 2H); MS 342 (M+1).

Provenance & Evidence