Pyridine-3-sulfonyl chloride hydrochloride → (3-{[(Pyridine-3-sulfonyl)-(4-pyrimidin-5-yl-benzyl)-amino]-methyl}-phenoxy)-acetic tert-butyl ester

Participants

Reaction Steps

The title compound of Step B was prepared from {3-[(4-pyrimidin-5-yl-benzylamino)-methyl]-phenoxy}-acetic acid tert-butyl ester of Step A and pyridine-3-sulfonyl chloride hydrochloride, of Preparation 2, followed the method described in Example 3, Step B 1H NMR (400 MHz, CDCl3) δ 9.19 (s, 1H), 9.05 (s, 1H), 8.89 (s, 2H), 8.79 (dd, 1H), 8.06 (m, 1H), 7.65 (m, 1H), 7.44 (m, 2H), 7.24 (m, 2H), 7.12 (t, 1H), 6.74 (dd, 1H), 6.66 (m, 2H), 4.42 (s, 2H), 4.39 (s, 2H), 4.34 (s, 2H), 1.47 (s, 9H); MS 547 (M+1).

Provenance & Evidence