Triethylamine → HCID 54411937, compound

HRID 2300517Notes

Reaction equation

HRID 2300517 reaction equation
[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15]CN)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[N:19]1([C:24]2[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=2)[CH:23]=[CH:22][N:21]=[CH:20]1.C([N:34](CC)CC)C>>[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:34][CH2:28][C:27]2[CH:30]=[CH:31][C:24]([N:19]3[CH:23]=[CH:22][N:21]=[CH:20]3)=[CH:25][CH:26]=2)[CH:10]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 7365304-(1H-imidazol-1-yl)benzaldehydeHCID 59479038HCID 59479038, compound

Product 1

HCID 54411937HCID 54411937, compound

Procedure

The title compound of Step A was prepared from (3-aminoethyl-phenoxy)-acetic acid tert-butyl ester, of Preparation 20, and 4-imidazol-1-yl-benzaldehyde, of Preparation 43, using the method described in Example 3, Step A, except no triethylamine was used. 1H NMR (400 MHz, CDCl3) δ 7.78 (s, 1H), 7.40 (d, 2H), 7.28 (d, 2H), 7.22 (m, 2H), 7.13 (m, 1H), 6.89 (m, 2H), 6.73 (m, 1H); 4.47 (s, 2H), 3.78 (s, 2H), 3.74 (s, 2H), 1.43 (s, 9H; MS 394 (M+1).

Sources & evidence

ORD record
ord-a8b3c44743ab4579a37a97b2cd65f395
Source dataset
uspto-grants-2002_12
Patent number
US06498172B1

Reaction notes

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