Hydrochloric Acid → (3-{[(3,5-Dimethyl-isoxazole-4-sulfonyl)-(4-pyrimidin-2-yl-benzyl)-amino]-methyl}-phenoxy)-acetic acid hydrochloride salt

Participants

Reaction Steps

The title compound was prepared following the method described in Example 3, Step C from (3-{[(3,5-dimethyl-isoxazole-4-sulfonyl)-(4-pyrimidin-2-yl-benzyl)-amino]-methyl}-phenoxy)-acetic acid tert-butyl ester of Step A. The HCl salt was prepared by treating the TFA salt with HCl in dioxane (4M) as described in Step C of Example 13i. 1H NMR (400 MHz, CDCl3) δ 8.92 (d, 1H, J=4.1 Hz), 8.25 (d, 1H, J=2.9 Hz), 7.55-6.71 (m, 8H), 6.62 (m, 1H), 4.55 (s, 2H), 4.52 (s, 2H), 4.45 (s, 2H), 2.62 (s, 3H), 2.43 (s, 3H); M 507 (M−1).

Provenance & Evidence