(R)-3-Methylmorpholine → (R)-4-[4-chloro-2-[(5-quinoxalinylsulfonyl)amino]benzoyl]-3-methylmorpholine

関与物質

役割	名称	HCID	仕込み量
反応物	(R)-3-Methylmorpholine	HCID 641498	—
反応物	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
反応物	4-Chloro-2-(quinoxaline-5-sulfonylamino)benzoic acid	HCID 16090778	—
生成物	(R)-4-[4-chloro-2-[(5-quinoxalinylsulfonyl)amino]benzoyl]-3-methylmorpholine	HCID 11293780	—

反応手順

The title compound was prepared from the HATU-mediated coupling of 4-chloro-2-(quinoxaline-5-sulfonylamino)benzoic acid (EXAMPLE 3, Step B) and (R)-3-methylmorpholine (EXAMPLE 12, Step B) and purified as described in EXAMPLE 1, Step K. MS (ESI): mass calculated for C20H19ClN4O4S, 446.1; m/z found, 445 [M−H]−. HPLC (reverse phase): RT=8.54 min. 1H NMR (500 MHz, CDCl3, rotameric broadening): 9.05 (d, J=1.8 Hz, 1H), 9.04 (br s, 1H), 9.00 (d, J=1.8 Hz, 1H), 8.56 (dd, J=7.0, 1.5 Hz, 1H), 8.37 (dd, J=8.4, 1.4 Hz, 1H), 7.91 (dd, J=8.4, 7.4 Hz, 1H), 7.56 (br s, 1H), 7.01-6.98 (m, 2H), 4.4-4.2 (br m, 1H), 3.90-3.82 (m, 1H), 3.68-3.62 (m, 1H), 3.51 (dd, J=11.5, 2.7 Hz, 1H), 3.40-3.20 (m, 3H), 1.31-1.23 (br m, 3H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07563895B2
出典データセット	uspto-grants-2009_07
ORD ID	ord-2b8ecf3d760740d180b982a26ec6ad64
出典メモ	uspto-grants-2009_07