4-Phenoxybenzaldehyde → HCID 54422415, compound

HRID 2300542Notes

Reaction equation

HRID 2300542 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:15])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][NH2:14])[CH:8]=1.[O:16]([C:23]1[CH:30]=[CH:29][C:26]([CH:27]=O)=[CH:25][CH:24]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH3:2][O:3][C:4](=[O:15])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][NH:14][CH2:27][C:26]2[CH:29]=[CH:30][C:23]([O:16][C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:24][CH:25]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 661394-PhenoxybenzaldehydeHCID 22282736Methyl 3-(3-(aminomethyl)phenyl)propanoate hydrochloride

Product 1

HCID 54422415HCID 54422415, compound

Procedure

The title compound of Step A was prepared from 3-(3-aminomethyl-phenyl)-propionic acid methyl ester hydrochloride salt, of Preparation 44, and 4-phenoxybenzaldehyde using the method described in Example 12z, Step A. 1H NMR (400 MHz, CDCl3) δ 7.37-6.95 (m, 13H), 3.82 (s, 2H), 3.79 (s, 2H), 3.64 (s, 3H), 2.93 (t, 2H), 2.63 (t, 2H); MS 376 (M+1).

Sources & evidence

ORD record
ord-b7d54cbe5deb44638f583a470d413d7f
Source dataset
uspto-grants-2002_12
Patent number
US06498172B1

Reaction notes

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