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HRID230055

反应详情

EQUATION

反应方程式

HRID 230055 的结构方程式

REACTANTS

反应物

3
结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

结构：O=C(O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12
HCID16090758

未命名化合物

结构：C[C@@H](N)c1ccc(F)cc1F.Cl
HCID44828513

(1R)-1-(2,4-Difluorophenyl)ethan-1-amine--hydrogen chloride (1/1)

C8H10ClF2N

PRODUCTS

生成物

1
结构：C[C@@H](NC(=O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12)c1ccc(F)cc1F
HCID11456125

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from the HATU-mediated coupling of 4-iodo-2-(quinoxaline-5-sulfonylamino)benzoic acid (EXAMPLE 4, Step D) and (R)-1-(2,4-difluorophenyl)ethylamine hydrochloride (EXAMPLE 2, Method 1, Step C) and purified as described in EXAMPLE 1, Step K. MS (ESI): mass calculated for C23H17F2IN4O3S, 594.0; m/z found, 593 [M−H]−. HPLC (reverse phase): RT=10.16 min. 1H NMR (500 MHz, CDCl3): 11.22 (s, 1H), 8.84 (d, J=1.8 Hz, 1H), 8.79 (d, J=1.8 Hz, 1H), 8.55 (dd, J=7.4, 1.4 Hz, 1H), 8.30 (dd, J=7.4, 1.4 Hz, 1H), 8.11 (d, J=1.8 Hz, 1H), 7.87 (dd, J=8.4, 7.4 Hz, 1H), 7.32-7.27 (m, 2H), 6.99 (d, J=8.2, 1H), 6.89-6.85 (m, 1H), 6.85-6.80 (m, 1H), 6.33 (br d, J=7.7 Hz, 1H), 5.35-5.27 (m, 1H), 1.53 (d, J=7.0 Hz, 3H).

WORKUP

后处理

  1. custompurified