6-hydroxy-1,4-naphthoquinone → HCID 18376526, compound

Participants

Reaction Steps

6-Hydroxynaphthoquinone (compound 2 prepared in step I above) (0.74 g, 2.35 mmol) was dissolved in 75% MeOH (30 mL) and powdered FeCl3·6H2O (1.65 g, 6.1 mmol) was added. The mixture was stirred for 4 h. The solvent was evaporated and the crude product (compound 3) was purified on silica gel with hexane:EtOAc 4:1. Yield: 0.27 g (47%). 1H NMR (400 MHz, Acetone-d6) δ 1.36 (s, 6 H), 6.90 (s, 1 H), 7.24 (dd, 1 H), 7.39 (d, 1 H), 7.94 (d, 1 H), 9.64 (s, 1 H).

Provenance & Evidence