Acetone → HCID 9922813, compound

Participants

Reaction Steps

To a solution of 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione (compound 1) (0.1 g, 0.415 mmol) in acetone (5 mL) was added K2CO3 (0.132 g, 0.96 mmol) while stirring at RT. After 10 minutes, MeI (0.058 g, 0,41 mmol) was added via a syringe and the mixture was allowed to stir for 1 h followed by addition of more MeI (0.058 g, 0,41 mmol) and the reaction was stirred over night. The solvent was removed in vacuum and the solid was dissolved in CHCl3, filtered and purified by preparative HPLC. Yield: 64 mg (50%). 1H NMR (400 MHz, CDCl3) δ 1.46 (d, 6 H), 2.12 (s, 3 H), 2.90 (s, 2 H), 3.65 (s, 3 H), 7.42 (t, 1 H), 7.55 (t, 1 H), 7.78 (d, 1 H), 7.94 (d, 1 H): MS (CI) m/z 314.36 (M+1).

Provenance & Evidence