Acetophenone → 1-(Phenyl)-1,3-heptanedione

Participants

Reaction Steps

The title compound was prepared (as described above for Intermediate 16) from 2.2 g (18.3 mmol) of acetophenone and 4.51 g (35 mmol) of ethyl valerate to yield 2.6 grams of Intermediate 18:: TLC Rf=0.52 (1/9 EtOAc/Hexanes); 1H NMR (400 MHz, CDCl3) δ7.87 (m, 2H), 7.48 (m, 3H), 6.17 (s,1H), 2.42 (t, 2H, J=7.6), 1.67 (m, 2H), 1.4 (m, 2H), 0.95 (t, 3H, J=7.2); low resolution MS (ES+)m/e 205.1 (MH+), 227.1 (M+Na+).

Provenance & Evidence