2,3-Difluorobenzaldehyde → HCID 18376318, compound

Participants

Reaction Steps

Intermediate 40 was prepared (as described above for intermediate 36) from 1-propynyllithium, 500 mg of 2,3-difluorobenzaldehyde, and 1.5 g of MnO2 to yield 440 mg of the title compound homogeneous by TLC (Rf=0.5, 2/1 hexanes/EtOAc); 1H NMR (400 MHz, CDCl3) δ7.82-7.86 (m, 1H), 7.43-7.35 (m 1H), 7.22-7.15 (m, 1H), 2.15 (s, 3H).

Provenance & Evidence