HRID2300613

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C

HCID7019130

Boc-Tyr-OMe

C15H21NO5

HCID10588172

2-{5-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}ethan-1-ol

C13H12F3NO2

PRODUCTS

生成物

结构：Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1CCOc1ccc(C[C@H](N)C(=O)O)cc1

HCID18343039

未命名化合物

PROCEDURE

实验过程

Intermediate 50 was prepared from 185 mg of N-(Boc)-L-Tyrosine methyl ester and 170 mg of Intermediate 13 to yield 130 mg (48% overall yield) of the title compound as a solid: 1H NMR (DMSO-d6, 400 MHz) δ8.16 (d, 2H, J=8.2), 7.92 (d, 2H, J=8.4), 7.21 (d, 2H, J=8.5), 6.93 (d, 2H, J=8.5), 4.25 (t, 2H, J=6.5), 3.1 (dd, 1H, J=14.4, 4.8), 3.0 (t, 2H, J=6.5), 2.76 (dd, 1H, J=14.4, 7.9), 2.46 (s, 3H); low resolution MS (ES+)m/e 434.9 (MH+).

WORKUP

后处理

customto yield