HRID2300615

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C

HCID7019130

Boc-Tyr-OMe

C15H21NO5

HCID11571932

(5-methyl-2-phenyl-1,3-oxazol-4-yl)methanol

C11H11NO2

结构：Cc1oc(-c2ccc(F)cc2)nc1CCOc1ccc(C[C@H](N)C(=O)O)cc1

HCID70159586

未命名化合物

PRODUCTS

生成物

结构：Cc1oc(-c2ccccc2)nc1COc1ccc(C[C@H](N)C(=O)O)cc1

HCID69835737

未命名化合物

PROCEDURE

实验过程

Amino acid Intermediate 54 was prepared as described for the preparation of Intermediate 46. From 187 mg of N-(Boc)-L-Tyrosine methyl ester and 120 mg of Intermediate 8D (with DIAD replacing DEAD) was prepared 116 mg (53% overall yield) of the title compound as a solid. 1H NMR (DMSO-d6, 300 MHz) δ7.89-7.85 (m, 2H), 7.43-7.36 (m, 3H), 7.12 (d, 2H, J=8.5), 6.9 (d, 2H, J=8.5), 4.9 (s, 2H), 3.63 (m, 1H), 3.0 (dd, 1H, J=14.4, 4.5), 2.85 (dd, 1H, J=14.4, 8.1), 2.37 (s, 3H); low resolution MS (ES+)m/e 353.07 (MH+).