Trifluoroacetic acid → HCID 70159644, compound

Participants

Role	Name	HCID	Charge
Reactant	Trifluoroacetic acid	HCID 6422	—
Reactant	1-(Pyridin-2-yl)butane-1,3-dione	HCID 12707221	—
Reactant	(2S)-2-amino-3-{4-[2-(5-methyl-2-phenyl-1,3oxazol-4-yl)ethoxy]phenyl}propanoic acid	HCID 18343040	—
Product	HCID 70159644	HCID 70159644	—

Reaction Steps

The title compound was prepared (as described above for the preparation of Example 2) from 441 mg (0.92 mmol) of Intermediate 45 (as the TFA salt) and 150 mg (0.92 mmol) of Intermediate 35 to yield 240 mg of Example 34: TLC (DCM/MeOH, 4/1): Rf=0.46; 1H NMR (DMSO-d6, 400 MHz) δ11.49 (d, 1H, J=9.2), 8.52 (d, 1H, J=4.8), 7.90 (m, 4H), 7.47 (m, 4H), 7.11 (d, 2H, J=8.4), 6.80 (d, 2H, J=8.4), 6.13 (s, 1H), 4.12 (m, 3H), 3.16 (m, 2H), 2.87 (t, 2H, J=6.4), 2.77 (dd, 1H, J=13.6, 9.2), 2.34 (s, 3H), 1.71 (s, 3H); low resolution MS (ES−)m/e 510.1 (M-H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06498174B1
Source dataset	uspto-grants-2002_12
ORD ID	ord-4fd1278b9b9e4ee79513fe42cda7f106
Source note	uspto-grants-2002_12