Triethylamine → HCID 69836749, compound

Participants

Reaction Steps

The title compound was prepared (as described above for the preparation of Example 2) from 1.35 g (2.72 mmol) of Intermediate 62, 630 mg (2.72 mmol) of Intermediate 24, and 0.8 mL triethylamine in MeOH (20 mL) and trimethylorthoformate (5 mL) to yield 1.04 g (65% yield) of Example 70 after silica gel chromatography (5%-15% MeOH in DCM): TLC (DCM/MeOH, 4/1): Rf=0.45; 1H NMR (DMSO-d6, 300 MHz) δ11.57 (d, 1H, J=8.7), 7.96 (d, 2H, J=8.4), 7.85 (m, 2H), 7.71 (d, 2H, J=8.4), 7.44 (m, 3H), 6.92 (d, 2H, J=8.4), 5.6 (s, 1H), 5.05 (s, 2H), 4.21-4.27 (m, 1H), 3.27-3.22 (m, 1H), 2.89-2.81 (m, 4H), 1.72 (s, 3H), 1.19 (t, 3H, J=7.5); low resolution MS (ES+)m/e 594.96 (MH+).

Provenance & Evidence