Triethylamine → HCID 69835843, compound

Participants

Reaction Steps

The title compound was prepared (as described above for the preparation of Example 2) from 176 mg (0.46 mmol) of Intermediate 63, 105 mg (0.46 mmol) of Intermediate 24, and 0.14 mL triethylamine in MeOH (3.0 mL) and trimethylorthoformate (0.75 mL) to yield 152 mg (56% yield) of Example 76 after silica gel chromatography (5%-15% MeOH in DCM): TLC (DCM/MeOH, 4/1): Rf=0.55; 1H NMR (DMSO-d6, 300 MHz) δ11.55 (d, 1H, J=9.0), 7.99-7.94 (m, 4H), 7.73 (d, 2H, J=8.4), 7.33 (t, 2H, J=8.7), 7.16 (d, 2H), J=8.4), 6.90 (d, 2H, J=8.7), 5.61 (s, 1H), 4.93 (s, 2H), 4.23-4.18 (m, 1H), 3.22-3.18 (m, 1H), 2.85-2.73 (m, 4H), 1.72 (s, 3H), 1.17 (t, 3H, J=7.5); low resolution MS (ES+)m/e 597.09 (MH+).

Provenance & Evidence